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SA EMS ROAD EXPERIENCEBased on HPCSA CDST v1.3 • Oct 2025
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HPCSA STATUTORY COMPLIANTOCT 2025 v1.3 • ANNEXURE A 2022

Drug Protocol Field Directory

Verified clinical pharmacology monographs aligned strictly with the HPCSA Professional Board for Emergency Care Clinical Practice Guidelines, CDST v1.3, and Annexure A (April 2022).

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Scope Ceilings & Typography Codes

CDST PG. 3
PLAIN TEXT
All Cadres (BAA No Color)
GREEN (*)
≥ AEA / ECA
ORANGE (^)
ANT / ECP
PURPLE (~)
ECP ONLY
Showing 61 of 61 MonographsA–Z ALPHABETICAL
Full Field Audio & Offline Speech Enabled
Antiplatelet Agent Audio Monograph
HPCSA CDST v1.3

ACETYLSALICYLIC ACID (ASPIRIN)

Acetylsalicylic Acid / ASA (Brand Names: Disprin, Ecotrin, Bayer Aspirin)

An irreversible cyclooxygenase-1 (COX-1) inhibitor that permanently halts platelet thromboxane A2 synthesis, preventing progressive occlusive thrombus propagation in acute coronary syndromes and ischemic heart disease.

Statutory Indications (1)
Suspected Acute Coronary Syndromes (STEMI / NSTEMI / Unstable Angina)
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Oral administration authorized across ALL cadres (Legendary BAA, AEA, ECA, ECT, CCA, NDip, ECP).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Gastrointestinal Adsorbent Audio Monograph
HPCSA CDST v1.3

ACTIVATED CHARCOAL

Activated Charcoal (Carbomix, Charcodote)

An oral gastrointestinal adsorbent with an enormous porous surface area that binds ingested xenobiotics, preventing enteral absorption and truncating enterohepatic recirculation.

Statutory Indications (1)
Acute Oral Toxin Ingestion (< 1 Hour Post-Ingestion)
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized across all registration categories (BAA, AEA, ECT, ECA, ANT, ECP) via oral or nasogastric/orogastric lavage within clinical guidelines.
4 Adverse Profiles•5 Contraindications
Open Drug Protocol
Antiarrhythmic Audio Monograph
HPCSA CDST v1.3

ADENOSINE

Adenosine (Brand Names: Adenocard, Adenoscan)

An ultra-short-acting endogenous purine nucleoside that transiently blocks AV nodal conduction to terminate paroxysmal supraventricular tachycardias.

Statutory Indications (2)
Paroxysmal Supraventricular Tachycardia (PSVT / AVNRT / AVRT)
Diagnostic Differentiation of Undifferentiated Regular Monomorphic Wide-Complex Tachycardia
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). CDST Tier: ORANGE (^). Restricted from BAA, AEA, ECA, and ECT.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Direct Sympathomimetic Agonist Audio Monograph
HPCSA CDST v1.3

ADRENALINE (EPINEPHRINE)

Adrenaline Acid Tartrate / Epinephrine (Brand Names: Adrenalin, EpiPen, Anapen)

A non-selective endogenous catecholamine that exerts potent direct alpha-1, beta-1, and beta-2 adrenergic receptor stimulation to restore coronary perfusion in arrest, reverse bronchospasm, and stabilize catastrophic anaphylactic shock.

Statutory Indications (3)
Severe Systemic Anaphylaxis & Life-Threatening Allergic Collapse
Cardiopulmonary Arrest (Shockable & Non-Shockable Rhythms)
Push-Dose Vasopressor & Post-ROSC Cardiogenic Shock Infusion
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): IM Anaphylaxis authorized across ALL cadres (Legendary BAA, AEA, ECA, ECT, CCA, NDip, ECP). IV Cardiac Arrest: AEA, ECA, ECT, ANT, ECP. IV Infusion/Push-dose: ANT and ECP (ECT requires supervising MO consult).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Class III Antiarrhythmic Audio Monograph
HPCSA CDST v1.3

AMIODARONE HYDROCHLORIDE

Amiodarone Hydrochloride (Brand Names: Cordarone, Nexterone, Pacerone)

A broad-spectrum Class III antiarrhythmic multichannel blocker with non-competitive alpha- and beta-blocking properties that prolongs cardiac action potential duration and refractoriness to terminate shock-refractory VF and stable wide-complex tachycardias.

Statutory Indications (2)
Shock-Refractory Ventricular Fibrillation (VF) & Pulseless VT (pVT)
Hemodynamically Stable Monomorphic Broad-Complex Tachycardia (VT)
Authorized HPCSA Scope of Practice:
ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV for Emergency Care Technicians (ECT), ALS Paramedics (Legendary CCA, NDip / ANT), and Emergency Care Practitioners (ECP).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Anticholinergic Audio Monograph
HPCSA CDST v1.3

ATROPINE SULPHATE

Atropine Sulphate (Brand Names: AtroPen)

A prototypical tertiary amine antimuscarinic agent that competitively blocks acetylcholine at post-ganglionic parasympathetic muscarinic receptors to accelerate sinoatrial nodal automaticity in unstable bradycardia and halt fatal bronchorrhea in organophosphate poisoning.

Statutory Indications (2)
Symptomatic, Hemodynamically Unstable Sinus Bradycardia
Organophosphate & Carbamate Insecticide Toxidrome (Cholinergic Crisis)
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Toxidromes (IM/IV): AEA, ECA, ECT, ANT, ECP. Hemodynamically Unstable Bradycardia (IV): ECT, ANT (Legendary CCA, NDip), and ECP.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Long-Acting Synthetic Glucocorticoid Audio Monograph
HPCSA CDST v1.3

BETAMETHASONE

Betamethasone Sodium Phosphate (Celestone Soluspan)

A potent fluorinated synthetic glucocorticoid that crosses the placenta to induce fetal pulmonary surfactant synthesis and accelerate lung maturation in threatened preterm delivery.

Statutory Indications (1)
Threatened Preterm Labor (24–34 Weeks Gestation)
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (* Mandatory Senior ECP / Supervising Medical Officer consultation required prior to administration).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Electrolyte Replacement Audio Monograph
HPCSA CDST v1.3

CALCIUM CHLORIDE (10% SOLUTION)

Calcium Chloride (10% Solution) / Calcium Gluconate (10%)

An essential parenteral electrolyte solution that provides immediate cardiac membrane stabilization against hyperkalemia and reverses calcium channel blocker toxicity.

Statutory Indications (3)
Severe Life-Threatening Hyperkalemia with Malignant ECG Changes
Calcium Channel Blocker (CCB) Overdose with Refractory Shock
Acute Severe Hypocalcemia & Massive Blood Transfusion Hypocalcemia
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). CDST Tier: ORANGE (^). Restricted from BAA, AEA, ECA, and ECT.
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Thienopyridine Antiplatelet Audio Monograph
HPCSA CDST v1.3

CLOPIDOGREL BISULFATE

Clopidogrel Bisulfate (Brand Names: Plavix, Clopivas)

A second-generation thienopyridine prodrug that irreversibly blocks platelet P2Y12 ADP receptors to inhibit arterial platelet aggregation in acute STEMI and NSTE-ACS.

Statutory Indications (1)
Acute ST-Elevation Myocardial Infarction (STEMI) Co-Therapy with Thrombolysis (Tenecteplase)
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 7: Authorized for ANT (Legendary CCA, NDip) and ECP. BAA, AEA, and ECT NOT permitted. CDST Tier: ORANGE (^) / PURPLE (~). Oral administration in confirmed STEMI.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Toxicological Antidote Complex Audio Monograph
HPCSA CDST v1.3

CYANIDE ANTIDOTE

Cyanide Antidotes: Hydroxocobalamin (Cyanokit) / Sodium Nitrite & Sodium Thiosulfate / Amyl Nitrite

A multi-modal toxicological antidote complex combining Hydroxocobalamin, Sodium Nitrite, and Sodium Thiosulfate that scavenges cyanide and reactivates mitochondrial cellular respiration.

Statutory Indications (1)
Acute Cyanide Toxicity / Closed-Space Smoke Inhalation with Profound Lactic Acidosis
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ANT and ECP within occupational health and safety systems and specialized industrial hazmat rescue.
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
First-Generation H1 Antihistamine Audio Monograph
HPCSA CDST v1.3

CYCLIZINE

Cyclizine Hydrochloride / Lactate (Valoid)

A first-generation piperazine histamine H1 receptor antagonist with central anticholinergic and antiemetic properties, targeting the chemoreceptor trigger zone and vestibular pathway.

Statutory Indications (1)
Severe Nausea & Vomiting / Prophylaxis in Opioid Administration
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Carbohydrate Substrate Audio Monograph
HPCSA CDST v1.3

DEXTROSE (GLUCOSE 10% & 50%)

Dextrose Monohydrate / D-Glucose (10%, 50% IV Solutions)

A hypertonic carbohydrate solution that immediately elevates serum glucose concentrations to reverse neuroglycopenic coma, seizures, and acute hypoglycemia.

Statutory Indications (2)
Symptomatic Hypoglycemia (Blood Glucose < 3.5 mmol/L with Altered Consciousness)
Hyperkalemia Membrane Neutralization Adjunct (With Insulin)
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV for AEA, ECA, ECT, ALS Paramedics (Legendary CCA, NDip / ANT), and Emergency Care Practitioners (ECP). CDST Tier: GREEN (*). Neonatal Dextrose 10% restricted to ANT/ECP.
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Benzodiazepine Audio Monograph
HPCSA CDST v1.3

DIAZEPAM

Diazepam (Brand Names: Valium, Pax, Diazemuls)

A long-acting benzodiazepine anticonvulsant and anxiolytic that enhances GABA-A receptor chloride conductance to terminate prolonged generalized seizures.

Statutory Indications (2)
Active Generalized Convulsive Status Epilepticus (Seizure Duration > 5 Minutes)
Severe Skeletal Muscle Spasm in Major Orthopedic Trauma & Tetanus
Authorized HPCSA Scope of Practice:
ECA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized across all routes for ECA, ECT, ALS Paramedics (Legendary CCA, NDip / ANT), and Emergency Care Practitioners (ECP). CDST Tier: GREEN (*).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Synthetic Inotropic Sympathomimetic Audio Monograph
HPCSA CDST v1.3

DOBUTAMINE

Dobutamine Hydrochloride (Dobutrex)

A synthetic sympathomimetic inotrope with potent Beta-1 receptor agonism that enhances myocardial contractility and stroke volume while reducing ventricular filling pressures in cardiogenic shock.

Statutory Indications (1)
Cardiogenic Shock / Severe Decompensated Heart Failure
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): For ECP and ANT - Not to be prescribed/supplied unless through direct Medical Practitioner prescription/supply. All other categories not permitted.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Endogenous Catecholamine Audio Monograph
HPCSA CDST v1.3

DOPAMINE

Dopamine Hydrochloride (Intropin)

A dose-dependent endogenous catecholamine inotrope, chronotrope, and vasopressor stimulating dopaminergic, beta-1, and alpha-1 adrenergic receptors in cardiogenic and septic shock.

Statutory Indications (1)
Cardiogenic Shock / Refractory Hypotension Failing Fluid Loading
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): For ECP and ANT - Not to be prescribed/supplied unless through direct Medical Practitioner prescription/supply. All other categories not permitted.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Low Molecular Weight Heparin (LMWH) Audio Monograph
HPCSA CDST v1.3

ENOXAPARIN

Enoxaparin Sodium (Clexane)

A low-molecular-weight heparin (LMWH) with high anti-Factor Xa to anti-Factor IIa activity, serving as essential antithrombin co-therapy in STEMI fibrinolysis and acute coronary syndromes.

Statutory Indications (1)
Adjunctive Anticoagulation in STEMI Fibrinolysis (Tenecteplase Co-Therapy)
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Subcutaneous / Intravenous).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
General Anesthetic Induction Agent Audio Monograph
HPCSA CDST v1.3

ETOMIDATE

Etomidate (Brand Names: Amidate, Hypnomidate)

A rapid-acting non-barbiturate carboxylated imidazole induction hypnotic that provides profound anesthesia with exceptional hemodynamic stability during emergency RSI.

Statutory Indications (1)
Rapid Sequence Intubation (RSI) Induction in Hemodynamically Compromised Trauma / Cardiac Shock
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized strictly for Emergency Care Practitioners (ECP) for Rapid Sequence Induction / Intubation. CDST Tier: PURPLE (~). Not permitted for BAA, AEA, ECA, ECT, or ANT.
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Short-Acting Beta-2 Adrenergic Agonist (SABA) Audio Monograph
HPCSA CDST v1.3

FENOTEROL

Fenoterol Hydrobromide (Berotec)

A rapid-acting, short-acting Beta-2 adrenergic receptor agonist (SABA) delivering potent bronchodilation and relief of acute bronchospasm in asthma and COPD.

Statutory Indications (1)
Acute Bronchospasm in Asthma, COPD, and Anaphylaxis
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized across all registration categories (BAA, AEA, ECT, ECA, ANT, ECP) via inhaled nebulization.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Synthetic Opioid Analgesic Audio Monograph
HPCSA CDST v1.3

FENTANYL CITRATE

Fentanyl Citrate (Brand Names: Sublimaze, Actiq, Durogesic)

A synthetic phenylpiperidine opioid agonist approximately 100 times more potent than morphine that produces rapid, hemodynamically stable analgesia without histamine release, but carries high risk of wooden chest syndrome if pushed rapidly.

Statutory Indications (2)
Severe Acute Traumatic Pain in Hemodynamically Fragile Patients
RSI Pre-treatment & Reflex Intracranial Pressure (ICP) Blunting
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized for Emergency Care Practitioners (ECP). Paramedics (ANT / Legendary CCA / NDip) require direct Medical Practitioner prescription/supply.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Benzodiazepine Receptor Antagonist Audio Monograph
HPCSA CDST v1.3

FLUMAZENIL

Flumazenil (Anexate)

A specific imidazobenzodiazepine competitive antagonist at the central GABA-A receptor complex, selectively reversing benzodiazepine sedation and respiratory depression.

Statutory Indications (1)
Iatrogenic Benzodiazepine Over-Sedation Post-Procedural Intervention
Authorized HPCSA Scope of Practice:
ECA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECT, ECA, ANT, and ECP for iatrogenic benzodiazepine overdose during procedural sedation; Authorized for ECP for general benzodiazepine reversal.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Loop Diuretic Audio Monograph
HPCSA CDST v1.3

FUROSEMIDE

Furosemide / Frusemide (Brand Names: Lasix)

A potent loop diuretic that inhibits the Na+/K+/2Cl- co-transporter in the thick ascending limb of Henle and induces rapid systemic venodilation to relieve acute cardiogenic pulmonary edema.

Statutory Indications (1)
Acute Cardiogenic Pulmonary Edema with Proven Fluid Overload
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). CDST Tier: ORANGE (^). Restricted from BAA, AEA, ECA, and ECT.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Pancreatic Hormone Audio Monograph
HPCSA CDST v1.3

GLUCAGON

Glucagon (Brand Names: GlucaGen, Glucagon Emergency Kit)

A recombinant peptide hormone that stimulates hepatic glycogenolysis to reverse severe hypoglycemia when IV access is impossible, and acts as a non-adrenergic inotrope in beta-blocker overdose.

Statutory Indications (2)
Severe Symptomatic Hypoglycemia (Unable to Establish IV Access)
Severe Beta-Blocker Overdose with Refractory Bradycardia & Shock
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized for ECA, ECT, ANT (Legendary CCA, NDip), and ECP. AEA requires mandatory Supervising Medical Officer consultation. CDST Tier: GREEN (*).
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Organic Nitrate Audio Monograph
HPCSA CDST v1.3

GLYCERYL TRINITRATE (GTN / NITROGLYCERIN)

Glyceryl Trinitrate / Nitroglycerin (Brand Names: Nitrolingual, Angised, Nitrostat)

An organic nitrate prodrug that undergoes enzymatic denitration to release nitric oxide, stimulating guanylyl cyclase to induce potent systemic venodilation and coronary artery dilatation, drastically reducing cardiac preload in acute angina and pulmonary edema.

Statutory Indications (2)
Acute Coronary Syndromes (Angina Pectoris / STEMI / NSTEMI)
Acute Cardiogenic Pulmonary Edema / SCAPE (Sympathetic Crashing Heart Failure)
Authorized HPCSA Scope of Practice:
ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Sublingual spray/tablet authorized for ECT, ALS Paramedics (Legendary CCA, NDip / ANT), and ECP. (AEA historically utilized under physician protocol).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Unfractionated Heparin (UFH) Audio Monograph
HPCSA CDST v1.3

HEPARIN SODIUM

Heparin Sodium (UFH)

An unfractionated glycosaminoglycan anticoagulant that potently accelerates Antithrombin III, inactivating thrombin and Factor Xa in acute STEMI PCI transfer and massive pulmonary embolism.

Statutory Indications (1)
Primary Percutaneous Coronary Intervention (PCI) Transfer / Massive Pulmonary Embolism
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Subcutaneous / Intravenous). For ANT, not permitted unless through direct Medical Practitioner prescription.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Direct-Acting Peripheral Vasodilator Audio Monograph
HPCSA CDST v1.3

HYDRALAZINE

Hydralazine Hydrochloride (Apresoline)

A direct-acting arteriolar vasodilator that relaxes vascular smooth muscle, reducing systemic vascular resistance and lowering severe blood pressure in pre-eclamptic hypertensive emergencies.

Statutory Indications (1)
Severe Hypertensive Emergency in Pre-Eclampsia / Eclampsia
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (* Mandatory Senior ECP / Supervising Medical Officer consultation required prior to administration).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Corticosteroid Audio Monograph
HPCSA CDST v1.3

HYDROCORTISONE SODIUM SUCCINATE

Hydrocortisone Sodium Succinate (Brand Names: Solu-Cortef)

A short-acting parenteral systemic glucocorticoid that inhibits inflammatory cascades and stabilizes capillary permeability in severe anaphylaxis, status asthmaticus, and adrenal crisis.

Statutory Indications (3)
Severe Systemic Anaphylaxis (Prevention of Biphasic Relapse)
Acute Life-Threatening Status Asthmaticus & Severe COPD Exacerbation
Acute Adrenal Crisis (Addisonian Shock)
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV/IM for AEA, ECA, ECT, ALS Paramedics (Legendary CCA, NDip / ANT), and Emergency Care Practitioners (ECP). CDST Tier: GREEN (*).
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Quaternary Ammonium Anticholinergic Audio Monograph
HPCSA CDST v1.3

HYOSCINE BUTYLBROMIDE

Hyoscine Butylbromide (Buscopan)

A quaternary ammonium antispasmodic that competitively antagonizes muscarinic receptors in gastrointestinal, biliary, and genitourinary smooth muscle, relieving acute colic.

Statutory Indications (1)
Acute Severe Visceral Spasm / Renal & Biliary Colic
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (* Mandatory Senior ECP / Supervising Medical Officer consultation required prior to administration).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
NSAID Audio Monograph
HPCSA CDST v1.3

IBUPROFEN

Ibuprofen (Brufen, Nurofen, Advil)

A propionic acid non-steroidal anti-inflammatory drug (NSAID) that non-selectively inhibits COX-1 and COX-2 enzymes to decrease prostaglandin synthesis in acute inflammatory pain.

Statutory Indications (1)
Mild to Moderate Musculoskeletal Pain & Inflammatory Soft Tissue Trauma
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ANT (* Mandatory Senior ECP / MO consultation required) and ECP (Oral).
3 Adverse Profiles•5 Contraindications
Open Drug Protocol
Anticholinergic Bronchodilator Audio Monograph
HPCSA CDST v1.3

IPRATROPIUM BROMIDE

Ipratropium Bromide (Brand Names: Atrovent, Duolin / Combivent with Salbutamol)

An anticholinergic bronchodilator that blocks muscarinic receptors on bronchial smooth muscle to reduce bronchospasm and dry excessive secretions.

Statutory Indications (2)
Acute Severe Bronchospasm in Asthma (Adjunct to Salbutamol)
Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Inhaled nebulization authorized across ALL registration categories (Legendary BAA, AEA, ECA, ECT, CCA, NDip, ECP). CDST Tier: PLAIN TEXT (No Color).
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Organic Nitrate Vasodilator Audio Monograph
HPCSA CDST v1.3

ISOSORBIDE DINITRATE

Isosorbide Dinitrate / Isosorbide Trinitrate (Isoket)

A long-acting organic nitrate vasodilator and nitric oxide donor that dilates venous capacitance beds and coronary arteries, dramatically reducing preload in acute pulmonary edema.

Statutory Indications (1)
Acute Cardiogenic Pulmonary Edema / Refractory Hypertensive Left Heart Failure
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous) (* Mandatory Senior ECP / Supervising Medical Officer consultation required prior to administration).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Dissociative Anesthetic Audio Monograph
HPCSA CDST v1.3

KETAMINE HYDROCHLORIDE

Ketamine Hydrochloride (Brand Names: Ketalar, Ketanest, Calypsol)

A rapid-acting dissociative anesthetic and potent analgesic that disrupts sensory perception and pain signaling while stimulating sympathetic tone to preserve blood pressure and spontaneous respiration.

Statutory Indications (3)
Rapid Sequence Intubation (RSI) / Drug-Assisted Airway Induction in Trauma
Post-Intubation Maintenance of Sedation & Anesthesia
Dissociative Procedural Analgesia & Severe Refractory Pain
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). Restricted from BAA, AEA, ECA, and ECT.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Combined Alpha/Beta-Adrenergic Receptor Blocker Audio Monograph
HPCSA CDST v1.3

LABETALOL

Labetalol Hydrochloride (Trandate)

A combined selective Alpha-1 and non-selective Beta-1/Beta-2 adrenergic receptor blocker that reduces systemic vascular resistance without precipitating reflex tachycardia.

Statutory Indications (1)
Acute Aortic Dissection / Severe Pre-Eclamptic Hypertensive Crisis
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous) (* Mandatory Senior ECP / Supervising Medical Officer consultation required prior to administration).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Class Ib Antiarrhythmic Audio Monograph
HPCSA CDST v1.3

LIGNOCAINE HYDROCHLORIDE (LIDOCAINE)

Lignocaine Hydrochloride / Lidocaine (1%, 2% Solutions)

A Class Ib antiarrhythmic and amide local anesthetic that blocks voltage-gated fast sodium channels to suppress ventricular ectopy and numb intraosseous medullary channels.

Statutory Indications (3)
Intraosseous (IO) Flush Local Anesthesia in Conscious Patients
Shock-Refractory Ventricular Fibrillation (VF) & Pulseless VT (Alternative to Amiodarone)
Stable Monomorphic Ventricular Tachycardia with Preserved Pulse
Authorized HPCSA Scope of Practice:
ECA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): IO Flush local anesthetic authorized for ECA, ECT, ANT, and ECP (CDST: GREEN *). IV Ventricular Arrhythmia management authorized for ANT and ECP (CDST: ORANGE ^).
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
High-Potency Benzodiazepine Audio Monograph
HPCSA CDST v1.3

LORAZEPAM

Lorazepam (Ativan)

A potent intermediate-acting benzodiazepine that enhances GABA-A receptor chloride conductance, serving as the first-line anticonvulsant for status epilepticus and severe violent agitation.

Statutory Indications (1)
Status Epilepticus & Prolonged Generalized Convulsive Seizures
Authorized HPCSA Scope of Practice:
ECA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECT, ECA, ANT, and ECP (Intramuscular and Intravenous).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Divalent Cation Audio Monograph
HPCSA CDST v1.3

MAGNESIUM SULPHATE

Magnesium Sulphate Heptahydrate (MgSO4 50% solution)

A physiological divalent cation that acts as an endogenous calcium antagonist and NMDA blocker to suppress eclamptic convulsions, relax bronchial smooth muscle in life-threatening asthma, and terminate polymorphic VT (Torsades de Pointes).

Statutory Indications (3)
Eclampsia & Severe Pre-Eclampsia with Imminent Convulsion Signs
Life-Threatening Acute Severe Asthma Failing Inhaled Bronchodilators
Torsades de Pointes (Polymorphic VT) & Cardiac Arrest
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): IM for Eclampsia: AEA (with MO consult), ECA, ECT, ANT, ECP. IV for Torsades / Severe Bronchospasm: ECT, ANT (Legendary CCA, NDip), ECP.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Medical Gas Audio Monograph
HPCSA CDST v1.3

MEDICAL OXYGEN

Medical Oxygen 100% (Compressed O2 Gas)

An essential therapeutic compressed gas providing vital cellular oxygenation to halt anaerobic metabolism and prevent ischemic end-organ failure in acute hypoxemia and shock.

Statutory Indications (1)
Acute Hypoxemia, Critical Illness & Severe Traumatic Shock
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized across all registration categories (BAA, AEA, ECT, ECA, ANT, ECP) via nasal cannula, simple face mask, venturi, non-rebreather mask (NRB), and bag-valve-mask.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Inhaled Analgesic Audio Monograph
HPCSA CDST v1.3

METHOXYFLURANE

Methoxyflurane (Brand Names: Penthrox, "The Green Whistle")

A rapidly acting, self-administered inhaled volatile fluorinated hydrocarbon analgesic delivered via the Penthrox inhaler for moderate to severe traumatic pain.

Statutory Indications (1)
Moderate to Severe Acute Traumatic Pain (Fractures, Dislocations, Burns, Crush Injuries)
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 9: Authorized for ALL Cadres (BAA, AEA, ECA, ECT, ANT, ECP). CDST Tier: PLAIN TEXT (All Cadres). Patient must self-administer.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Synthetic Glucocorticoid Audio Monograph
HPCSA CDST v1.3

METHYLPREDNISOLONE

Methylprednisolone Sodium Succinate (Solu-Medrol)

An intermediate-acting synthetic glucocorticoid with potent genomic and non-genomic anti-inflammatory activity, reversing airway mucosal edema and blunting cytokine cascades.

Statutory Indications (1)
Severe Acute Asthma & COPD Exacerbations / Biphasic Anaphylaxis Prophylaxis
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for AEA, ECT, ECA, ANT, and ECP (Intravenous or Intramuscular).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Dopamine D2 Receptor Antagonist Audio Monograph
HPCSA CDST v1.3

METOCLOPRAMIDE HYDROCHLORIDE

Metoclopramide Hydrochloride (Brand Names: Maxolon, Clopamon, Primperan)

A prokinetic dopamine D2 antagonist and antiemetic that accelerates upper GI motility and blocks chemoreceptor trigger zone emetic signaling.

Statutory Indications (1)
Severe Nausea and Vomiting (Trauma, Migraine, Opioid-Induced, Post-Operative)
Authorized HPCSA Scope of Practice:
ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 9: Authorized for ECT, ANT (Legendary CCA, NDip), and ECP. BAA and AEA NOT permitted. Must be pushed slowly over at least 2–3 minutes.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Benzodiazepine Audio Monograph
HPCSA CDST v1.3

MIDAZOLAM HYDROCHLORIDE

Midazolam Hydrochloride (Brand Names: Dormicum, Versed, Hypnovel)

A rapid-acting, water-soluble imidazobenzodiazepine that acts as a positive allosteric modulator at central GABA-A receptors, delivering potent anticonvulsant, amnestic, and sedative effects for status epilepticus and emergency procedural sedation.

Statutory Indications (3)
Status Epilepticus & Prolonged Generalized Convulsive Seizures
Severe Acute Behavioral Agitation & Combative Delirium
Post-Intubation Maintenance Sedation & Procedural Sedation
Authorized HPCSA Scope of Practice:
ECA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized across all routes for ECA, ECT, ALS Paramedics (Legendary CCA, NDip / ANT), and ECP. AEA requires specific PBEC CPD update or MO consult.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Opioid Analgesic Audio Monograph
HPCSA CDST v1.3

MORPHINE SULPHATE

Morphine Sulphate (Brand Names: Morphine, MST Continus, Sevredol)

A prototypical natural phenanthrene alkaloid opioid that binds stereospecifically to central and spinal mu-opioid receptors to attenuate nociceptive transmission, alleviate severe acute pain, and reduce cardiac preload in acute pulmonary edema.

Statutory Indications (2)
Severe Acute Traumatic Pain & Musculoskeletal Injuries
Acute Coronary Syndromes (Nitrate-Refractory Ischemic Chest Pain)
Authorized HPCSA Scope of Practice:
ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). ECT permitted with mandatory Supervising Medical Officer consultation.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Pure Opioid Receptor Antagonist Audio Monograph
HPCSA CDST v1.3

NALOXONE HYDROCHLORIDE

Naloxone Hydrochloride (Brand Names: Narcan, Nyxoid, Prenoxad)

A pure competitive opioid receptor antagonist with high affinity for mu-opioid receptors that displaces opioids to rapidly reverse life-threatening opioid-induced respiratory depression and coma.

Statutory Indications (2)
Acute Opioid Overdose with Severe Respiratory Depression & Coma
Cardiopulmonary Arrest with Suspected Opioid Overdose
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized across all routes for ECA, ECT, ALS Paramedics (Legendary CCA, NDip / ANT), and ECP. AEA requires MO consult or PBEC CPD update.
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Reversible Acetylcholinesterase Inhibitor Audio Monograph
HPCSA CDST v1.3

NEOSTIGMINE

Neostigmine Methylsulfate (Prostigmin)

A reversible anticholinesterase quaternary amine that elevates acetylcholine concentrations at the neuromuscular junction to reverse non-depolarizing neuromuscular blockade.

Statutory Indications (1)
Active Reversal of Non-Depolarizing Neuromuscular Blockade (Vecuronium / Rocuronium)
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Dihydropyridine Calcium Channel Blocker (CCB) Audio Monograph
HPCSA CDST v1.3

NIFEDIPINE

Nifedipine (Adalat, Adalat Retard)

A dihydropyridine L-type calcium channel blocker delivering selective peripheral arteriolar vasodilation to lower severe blood pressure in pre-eclampsia and tocolyze preterm labor.

Statutory Indications (1)
Severe Pre-Eclampsia Hypertensive Emergency / Tocolysis in Preterm Labor
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): For ECP - Not to be prescribed/supplied unless through direct Medical Practitioner prescription/supply. All other categories not permitted.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Inhaled Dissociative Analgesic Audio Monograph
HPCSA CDST v1.3

NITROUS OXIDE / OXYGEN (ENTONOX)

Nitrous Oxide & Oxygen (50%:50%) (Brand Names: Entonox, Nitronox)

An inhaled premixed 50:50 medical gas providing rapid, self-administered analgesic and mild anxiolytic effects for acute pain in trauma, burns, and labor.

Statutory Indications (1)
Moderate to Severe Acute Traumatic Pain, Burns, & Active Labor
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 9: Authorized for ALL Cadres (BAA, AEA, ECA, ECT, ANT, ECP). CDST Tier: PLAIN TEXT (All Cadres). Patient must self-administer via demand valve.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Selective 5-HT3 Receptor Antagonist Audio Monograph
HPCSA CDST v1.3

ONDANSETRON HYDROCHLORIDE

Ondansetron Hydrochloride (Brand Names: Zofran, Vomigo)

A highly selective 5-HT3 serotonin receptor antagonist delivering potent, non-sedating antiemesis without extrapyramidal side effects, indicated for severe nausea and vomiting.

Statutory Indications (1)
Severe Intractable Nausea and Vomiting (Trauma, Chemotherapy, Post-Operative, Opioid-Induced)
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 9: Authorized strictly for ECP Only. BAA, AEA, ECT, and ANT NOT permitted. CDST Tier: PURPLE (~). Administer slow IV push over 2–5 minutes.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Uterotonic Audio Monograph
HPCSA CDST v1.3

OXYTOCIN

Oxytocin (Brand Names: Syntocinon, Pitocin)

A synthetic nonapeptide hormone that stimulates uterine smooth muscle oxytocin receptors to induce rhythmic contractions and prevent fatal postpartum hemorrhage (PPH).

Statutory Indications (2)
Active Management of the Third Stage of Labor (AMTSL) & PPH Prophylaxis
Postpartum Hemorrhage (PPH) Secondary to Uterine Atony
Authorized HPCSA Scope of Practice:
ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized for Emergency Care Practitioners (ECP). Mandatory Senior ECP or Supervising Medical Officer consultation required for ECT and ANT (CCA / NDip). CDST Tier: GREEN (*) / ORANGE (^).
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Non-Opioid Analgesic Audio Monograph
HPCSA CDST v1.3

PARACETAMOL (ACETAMINOPHEN / PERFALGAN)

Paracetamol / Acetaminophen (Brand Names: Perfalgan IV, Panado, Calpol)

An intravenous and oral non-opioid central analgesic and antipyretic acting via central cyclooxygenase inhibition and cannabinoid/TRPV1 receptor modulation.

Statutory Indications (1)
Mild to Moderate Acute Pain & Multimodal Analgesic Adjunct in Severe Trauma
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 10: Authorized for ECP and ANT (Legendary CCA, NDip). ANT requires mandatory Supervising Medical Officer consultation (*). Must be infused over 15 minutes.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Synthetic Glucocorticoid Audio Monograph
HPCSA CDST v1.3

PREDNISOLONE

Prednisolone / Prednisone

An oral intermediate-acting synthetic glucocorticoid that suppresses inflammatory cascades, reduces mucosal edema, and halts late-phase bronchoconstriction in asthma and croup.

Statutory Indications (1)
Acute Asthma Exacerbation & Severe Croup (Laryngotracheobronchitis)
Authorized HPCSA Scope of Practice:
ECA (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECA, ANT, and ECP (Oral).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
First-Generation Phenothiazine Antihistamine Audio Monograph
HPCSA CDST v1.3

PROMETHAZINE HYDROCHLORIDE

Promethazine Hydrochloride (Brand Names: Phenergan, Avomine)

A first-generation phenothiazine antihistamine, antiemetic, and sedative acting as a potent competitive H1 and muscarinic antagonist.

Statutory Indications (2)
Severe Allergic Reactions / Adjunct in Systemic Anaphylaxis (Post-Adrenaline)
Severe Intractable Nausea and Vomiting / Motion Sickness
Authorized HPCSA Scope of Practice:
ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 10: Authorized for ECT, ANT (Legendary CCA, NDip), and ECP. BAA and AEA NOT permitted. Deep IM is the preferred route of administration.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Non-Depolarizing Neuromuscular Blocker Audio Monograph
HPCSA CDST v1.3

ROCURONIUM BROMIDE

Rocuronium Bromide (Brand Names: Esmeron, Zemuron)

An intermediate-acting non-depolarizing aminosteroid neuromuscular blocker that competitively antagonizes nicotinic acetylcholine receptors at the motor endplate, providing rapid, safe skeletal muscle flaccidity for emergency endotracheal intubation.

Statutory Indications (2)
Rapid Sequence Intubation (RSI) / Emergency Neuromuscular Blockade
Post-Intubation Ventilator Dyssynchrony & Long-Distance Transport
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized strictly for Emergency Care Practitioners (ECP) for Rapid Sequence Induction / Intubation. Not permitted for BAA, AEA, ECA, ECT, or ANT (CCA / NDip).
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Selective Beta-2 Adrenergic Agonist Audio Monograph
HPCSA CDST v1.3

SALBUTAMOL SULPHATE

Salbutamol Sulphate / Albuterol (Brand Names: Ventolin, Asthavent, ProAir)

A short-acting selective beta-2 adrenergic agonist that stimulates adenylyl cyclase to increase cyclic AMP in bronchial smooth muscle, triggering rapid bronchodilation in severe asthma/COPD and shifting potassium intracellularly in hyperkalemia.

Statutory Indications (2)
Acute Severe Asthma & COPD Bronchospasm Exacerbation
Severe Hyperkalemia with ECG Conduction Delay (Adjunctive Therapy)
Authorized HPCSA Scope of Practice:
LEGENDARY BAA (PLAIN)ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Nebulized / Inhaled: Authorized for ALL cadres (Legendary BAA, AEA, ECA, ECT, CCA, NDip, ECP). IV Infusion: ECT, ANT, ECP.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Systemic Alkalinizer Audio Monograph
HPCSA CDST v1.3

SODIUM BICARBONATE (8.5% SOLUTION)

Sodium Bicarbonate 8.5% (1 mmol/mL / 1 mEq/mL Solution)

A hypertonic alkalinizing agent that unbinds tricyclic antidepressants from myocardial fast sodium channels and drives intracellular potassium shifting in severe metabolic acidosis.

Statutory Indications (3)
Tricyclic Antidepressant (TCA) Cardiotoxicity & QRS Widening
Severe Hyperkalemic Cardiac Arrest / Dialysis Arrest with Sine-Wave Morphology
Severe Crush Injury / Traumatic Rhabdomyolysis (Urinary Alkalinization)
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized IV for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). CDST Tier: ORANGE (^). Restricted from BAA, AEA, ECA, and ECT.
3 Adverse Profiles•2 Contraindications
Open Drug Protocol
Vaughan-Williams Class III Antiarrhythmic Audio Monograph
HPCSA CDST v1.3

SOTALOL

Sotalol Hydrochloride (Sotacor)

A unique dual-action Class III antiarrhythmic and non-selective Beta-blocker that prolongs cardiac action potential duration and refractoriness to terminate tachyarrhythmias.

Statutory Indications (1)
Hemodynamically Stable Supraventricular & Ventricular Tachyarrhythmias
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous) (* Mandatory Senior ECP / Supervising Medical Officer consultation required prior to administration).
3 Adverse Profiles•5 Contraindications
Open Drug Protocol
First-Generation Fibrinolytic Audio Monograph
HPCSA CDST v1.3

STREPTOKINASE

Streptokinase (Streptase)

A bacterial plasminogen activator that forms an active stoichiometric complex to generate plasmin, dissolving coronary and pulmonary intravascular fibrin thrombi.

Statutory Indications (1)
Acute ST-Elevation Myocardial Infarction (STEMI) Within 12 Hours
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous) (Alternative fibrinolytic when Tenecteplase is unavailable).
4 Adverse Profiles•5 Contraindications
Open Drug Protocol
Selective Relaxant Binding Agent (SRBA) Audio Monograph
HPCSA CDST v1.3

SUGAMMADEX

Sugammadex Sodium (Bridion)

A modified gamma-cyclodextrin selective relaxant binding agent that encapsulates and inactivates rocuronium and vecuronium, achieving instant reversal in 'cannot intubate, cannot oxygenate' crises.

Statutory Indications (1)
Emergency Reversal in 'Cannot Intubate, Cannot Oxygenate' (CICO) Airway Crises
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous).
4 Adverse Profiles•3 Contraindications
Open Drug Protocol
Depolarizing Neuromuscular Blocker Audio Monograph
HPCSA CDST v1.3

SUXAMETHONIUM CHLORIDE (SUCCINYLCHOLINE)

Suxamethonium Chloride / Succinylcholine (Brand Names: Scoline, Anectine, Quelicin)

An ultra-rapid, short-acting depolarizing neuromuscular blocker composed of two linked acetylcholine molecules that produces immediate motor endplate depolarization and profound flaccidity within 45 seconds for emergency RSI.

Statutory Indications (1)
Rapid Sequence Intubation (RSI) in Uncomplicated Airway Emergencies
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized strictly for Emergency Care Practitioners (ECP) for neuromuscular blockade. Not permitted for BAA, AEA, ECA, ECT, or ANT (CCA / NDip).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Third-Generation Fibrinolytic / Thrombolytic Agent Audio Monograph
HPCSA CDST v1.3

TENECTEPLASE (TNK-tPA / METALYSE)

Tenecteplase (Brand Names: Metalyse, TNKase)

A third-generation bio-engineered recombinant fibrinolytic agent administered as a single weight-adjusted IV bolus for pre-hospital STEMI reperfusion.

Statutory Indications (1)
Acute ST-Segment Elevation Myocardial Infarction (STEMI) Within 12 Hours of Symptom Onset (When PCI Delay > 120 Minutes)
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022) p. 10: Authorized strictly for ECP Only. BAA, AEA, ECT, and ANT NOT permitted. CDST Tier: PURPLE (~). Strict weight-based single IV bolus over 5–10 seconds.
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Water-Soluble Vitamin B1 Audio Monograph
HPCSA CDST v1.3

THIAMINE

Thiamine Hydrochloride (Betamin, Vitamin B1)

An essential water-soluble B-complex vitamin cofactor (Vitamin B1) mandatory before or alongside IV dextrose to prevent precipitating acute Wernicke-Korsakoff encephalopathy.

Statutory Indications (1)
Prevention & Treatment of Wernicke-Korsakoff Syndrome / Severe Malnutrition with Hypoglycemia
Authorized HPCSA Scope of Practice:
ECA (*)AEA (*)ECT (*)LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for AEA, ECT, ECA, ANT, and ECP (Intramuscular).
3 Adverse Profiles•1 Contraindications
Open Drug Protocol
Antifibrinolytic Audio Monograph
HPCSA CDST v1.3

TRANEXAMIC ACID (TXA)

Tranexamic Acid (Brand Names: Cyklokapron, Transamin, Lysteda)

A synthetic lysine analogue antifibrinolytic that competitively blocks plasminogen activation to preserve forming blood clots, preventing catastrophic exsanguination in severe polytrauma and postpartum hemorrhage.

Statutory Indications (2)
Severe Polytrauma with Major Hemorrhage & Shock
Postpartum Hemorrhage (PPH) & Massive Obstetric Bleeding
Authorized HPCSA Scope of Practice:
LEGENDARY CCA (^)NDIP EMC (^)ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (2022): Authorized for ALS Paramedics (Legendary CCA, NDip / ANT) and Emergency Care Practitioners (ECP). ECT requires mandatory Senior ECP or Supervising Medical Officer consultation.
3 Adverse Profiles•3 Contraindications
Open Drug Protocol
Aminosteroid Non-Depolarizing Neuromuscular Blocker (NDNMB) Audio Monograph
HPCSA CDST v1.3

VECURONIUM

Vecuronium Bromide (Norcuron)

An intermediate-acting aminosteroid non-depolarizing neuromuscular blocker that competitively antagonizes nicotinic acetylcholine receptors, providing muscle relaxation for mechanical ventilation.

Statutory Indications (1)
Maintenance Neuromuscular Blockade During Mechanical Ventilation / Alternative RSI Agent
Authorized HPCSA Scope of Practice:
ECP ONLY (~)
⚖️ Scope Note:HPCSA Annexure A (April 2022): Authorized for ECP (Intravenous).
3 Adverse Profiles•4 Contraindications
Open Drug Protocol
Emergency Care Cadre Scope MandateAll drug dosages, routes, and clinical indications displayed herein must strictly adhere to the registered practitioner's HPCSA scope of practice (Emergency Care Assistant, Ambulance Emergency Assistant, Emergency Care Technician, or Emergency Care Practitioner).